Protein phase instability developed in plasma of sick patients: clinical observations and model experiments

This article discusses the causes of formation of micron-size protein structures in liquid plasma or serum of the patients with different diseases, which are accompanied by inflammatory reactions. Self-organizing processes in sessile drying drops of natural and model biological liquids are used for study of possible mechanisms of development the protein phase instability in serum. There was shown that violation of optimal ratio between albumin and osmotic active components could lead to loss of albumin aggregative stability and albumin coagulation structures formation. Possible role of these structures in pathogenesis of inflammation is discussed.